| PDB ID | 1B3K
|
CHAIN | A |
|---|---|---|---|
| Protein name | PLASMINOGEN ACTIVATOR INHIBITOR-1 | ||
| Uniprot Accession | P05121 | ||
| The number of similar proteins | 30 | ||
| The number of binding states | 7 | ||
| The number of binding partners | 5 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1B3K (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
P04004
|
| 3 |
P00750
|
| 4 |
6GWQ
|
| 5 |
P05121
|
| 6 |
6I8S
6I8S
|
| 7 |
6GWP
6GWP
|
Downdload
Molecule viewer
|
Only interaction residues |
|
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|
Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 7_TYR | HIS |
8.3kJPN chr7:100771762 rs969458866 |
- | 0.0001 | 0.0801 | - | |
| 7_TYR | CYS |
8.3kJPN chr7:100771763 - |
- | 0.0001 | 0.1268 | - | |
| 8_VAL | MET |
gnomAD chr7:100771765 rs141347752 |
- | 0.000501245 | 0.1923 | - | |
| 23_VAL | ALA |
8.3kJPN chr7:100771811 rs1174856192 |
- | 0.0001 | 0.1873 | - | |
| 32_VAL | MET |
8.3kJPN chr7:100771837 rs1384573586 |
- | 0.0001 | 0.1629 | - | |
| 66_ILE | THR |
8.3kJPN chr7:100771940 rs766305135 |
- | 0.0004 | 0.0997 | - | |
| 81_GLU | ASP |
8.3kJPN chr7:100773742 - |
- | 0.0001 | 0.1682 | - | |
| 120_THR | MET |
8.3kJPN chr7:100773858 rs775562788 |
- | 0.0001 | 0.1558 | - | |
| 157_VAL | MET |
gnomAD chr7:100775188 rs553824895 |
- | 0.000242566 | 0.2045 | - | |
| 184_THR | ILE |
gnomAD chr7:100775270 rs149389532 |
- | 0.000151398 | 0.6375 | - | |
| 186_ARG | HIS |
VAR_013087
rs2227669 |
LB/B | - | 0.0714 | - | |
| 209_ASN | SER |
gnomAD chr7:100775345 rs147003064 |
- | 0.000231325 | 0.0928 | - | |
| 215_THR | MET |
8.3kJPN chr7:100776988 rs201327802 |
- | 0.0002 | 0.17 | - | |
| 220_TYR | CYS |
8.3kJPN chr7:100777003 rs13306846 |
- | 0.0011 | 0.1375 | - | |
| 230_GLY | ARG |
gnomAD chr7:100777032 rs771305881 |
- | 0.000147145 | 0.4486 | - | |
| 231_ASP | GLY |
8.3kJPN chr7:100777036 - |
- | 0.0001 | 0.1406 | - | |
| 232_THR | ASN |
VAR_013088
rs2227685 |
LB/B | - | 0.1334 | - | |
| 257_GLN | ARG |
gnomAD chr7:100777114 rs543475314 |
- | 0.000111352 | 0.0982 | - | |
| 269_LEU | ARG |
8.3kJPN chr7:100777150 - |
- | 0.0001 | 0.1437 | - | |
| 294_GLY | GLU |
8.3kJPN chr7:100778825 - |
- | 0.0004 | 0.6569 | - | |
| 300_ARG | LYS |
8.3kJPN chr7:100778843 - |
- | 0.0001 | 0.1315 | - | |
| 353_ILE | VAL |
8.3kJPN chr7:100780320 - |
- | 0.0001 | 0.0883 | - | |
| 363_ARG | TRP |
8.3kJPN chr7:100780350 rs1379773181 |
- | 0.0001 | 0.2412 | - | |
| 366_PRO | SER |
8.3kJPN chr7:100780359 - |
- | 0.0004 | 0.2275 | - | |
| 377_MET | ILE |
8.3kJPN chr7:100780714 - |
- | 0.0001 | 0.5361 | - |