PDB ID 1B3K     CHAIN A
Protein name PLASMINOGEN ACTIVATOR INHIBITOR-1
Uniprot Accession P05121
The number of similar proteins 30
The number of binding states 7
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1B3K (CHAIN: A)
1 Monomeric state
2 P04004  
3 P00750  
4 6GWQ  
5 P05121  
6 6I8S   6I8S  
7 6GWP   6GWP  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  3
  2
  1
  0

Sequence information

1   VHHPPSYVAH   LASDFGVRVF   QQVAQASKDR   NVVFSPYGVA   SVLAMLQLTT   50
51   GGETQQQIQA   AMGFKIDDKG   MAPALRHLYK   ELMGPWNKDE   ISTTDAIFVQ   100
101   RDLKLVQGFM   PHFFRLFRST   VKQVDFSEVE   RARFIINDWV   KTHTKGMISH   150
151   LLGTGAVDQL   TRLVLVNALY   FNGQWKTPFP   DSSTHRRLFH   KSDGSTVSVP   200
201   MMAQTNKFNY   TEFTTPDGHY   YDILELPYHG   DTLSMFIAAP   YEKEVPLSAL   250
251   TNILSAQLIS   HWKGNMTRLP   RLLVLPKFSL   ETEVDLRKPL   ENLGMTDMFR   300
301   QFQADFTSLS   DQEPLHVALA   LQKVKIEVNE   SGTVASSSTA   VIVSARMAPE   350
351   EIIIDRPFLF   VVRHNPTGTV   LFMGQVMEP       400

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
7_TYR HIS 8.3kJPN
chr7:100771762 		rs969458866
- 0.0001 -
7_TYR CYS 8.3kJPN
chr7:100771763 		-
- 0.0001 -
8_VAL MET gnomAD
chr7:100771765 		rs141347752
- 0.000501245 -
23_VAL ALA 8.3kJPN
chr7:100771811 		rs1174856192
- 0.0001 -
32_VAL MET 8.3kJPN
chr7:100771837 		rs1384573586
- 0.0001 -
66_ILE THR 8.3kJPN
chr7:100771940 		rs766305135
- 0.0004 -
81_GLU ASP 8.3kJPN
chr7:100773742 		-
- 0.0001 -
120_THR MET 8.3kJPN
chr7:100773858 		rs775562788
- 0.0001 -
157_VAL MET gnomAD
chr7:100775188 		rs553824895
- 0.000242566 -
184_THR ILE gnomAD
chr7:100775270 		rs149389532
- 0.000151398 -
186_ARG HIS VAR_013087 rs2227669
LB/B - -
209_ASN SER gnomAD
chr7:100775345 		rs147003064
- 0.000231325 -
215_THR MET 8.3kJPN
chr7:100776988 		rs201327802
- 0.0002 -
220_TYR CYS 8.3kJPN
chr7:100777003 		rs13306846
- 0.0011 -
230_GLY ARG gnomAD
chr7:100777032 		rs771305881
- 0.000147145 -
231_ASP GLY 8.3kJPN
chr7:100777036 		-
- 0.0001 -
232_THR ASN VAR_013088 rs2227685
LB/B - -
257_GLN ARG gnomAD
chr7:100777114 		rs543475314
- 0.000111352 -
269_LEU ARG 8.3kJPN
chr7:100777150 		-
- 0.0001 -
294_GLY GLU 8.3kJPN
chr7:100778825 		-
- 0.0004 -
300_ARG LYS 8.3kJPN
chr7:100778843 		-
- 0.0001 -
353_ILE VAL 8.3kJPN
chr7:100780320 		-
- 0.0001 -
363_ARG TRP 8.3kJPN
chr7:100780350 		rs1379773181
- 0.0001 -
366_PRO SER 8.3kJPN
chr7:100780359 		-
- 0.0004 -
377_MET ILE 8.3kJPN
chr7:100780714 		-
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.