PDB ID 1AWI     CHAIN A
Protein name PROFILIN
Uniprot Accession P07737
The number of similar proteins 23
The number of binding states 6
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1AWI (CHAIN: A)
1 P07737  
2 Monomeric state
3 P68135  
4 P68135   Q93015  
5 P68135   P50552  
6 A0A6N3LUE9   P68135  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   GWNAYIDNLM   ADGTCQDAAI   VGYKDSPSVW   AAVPGKTFVN   ITPAEVGVLV   50
51   GKDRSSFYVN   GLTLGGQKCS   VIRDSLLQDG   EFSMDLRTKS   TGGAPTFNVT   100
101   VTKTDKTLVL   LMGKEGVHGG   LINKKCYEMA   SHLRRSQY     150

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
28_PRO LEU 8.3kJPN
chr17:4851604
rs769909149
- 0.0002 0.7374 -
51_VAL ALA 8.3kJPN
chr17:4850093
-
- 0.0001 0.5176 -
70_CYS GLY VAR_068925
rs387907264
LP/P - 0.9219 Amyotrophic lateral sclerosis 18 (ALS18) [MIM:614808]
70_CYS GLY ClinVar
chr17:4850037
rs387907264
Pathogenic - 0.9219 Amyotrophic lateral sclerosis type 18 [MONDO:MONDO:0013891,MedGen:C3553719,OMIM:614808,Orphanet:803]
113_MET THR VAR_068926
rs387907265
LP/P - 0.9563 Amyotrophic lateral sclerosis 18 (ALS18) [MIM:614808]
113_MET THR ClinVar
chr17:4849277
rs387907265
Pathogenic - 0.9563 Amyotrophic lateral sclerosis type 18|not provided [MONDO:MONDO:0013891,MedGen:C3553719,OMIM:614808,Orphanet:803|MedGen:C3661900]
113_MET ARG ClinVar
chr17:4849277
rs387907265
Likely pathogenic - 0.8952 Lower limb muscle weakness [Human Phenotype Ontology:HP:0002065,Human Phenotype Ontology:HP:0002477,Human Phenotype Ontology:HP:0007340,Human Phenotype Ontology:HP:0009047,MedGen:C1836296]
116_GLU GLY VAR_068927
rs140547520
US - 0.8396 Amyotrophic lateral sclerosis 18 (ALS18) [MIM:614808]
116_GLU ASP gnomAD
chr17:4849267
rs151313170
- 0.000481152 0.413 -
116_GLU GLY gnomAD
chr17:4849268
rs140547520
- 0.000497053 0.8396 -
117_GLY VAL VAR_068928
rs387907266
LP/P - 0.9839 Amyotrophic lateral sclerosis 18 (ALS18) [MIM:614808]
117_GLY VAL ClinVar
chr17:4849265
rs387907266
Pathogenic - 0.9839 Amyotrophic lateral sclerosis type 18 [MONDO:MONDO:0013891,MedGen:C3553719,OMIM:614808,Orphanet:803]
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.