PDB ID 1AV1     CHAIN A
Protein name APOLIPOPROTEIN A-I
Uniprot Accession P02647
The number of similar proteins 29
The number of binding states 5
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1AV1 (CHAIN: A)
1 P02647   P02647   P02647  
2 P02647  
3 8VXJ   8VXJ  
4 P02647   P04049  
5 P02647   P01116  

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Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   MLKLLDNWDS   VTSTFSKLRE   QLGPVTQEFW   DNLEKETEGL   RQEMSKDLEE   50
51   VKAKVQPYLD   DFQKKWQEEM   ELYRQKVEPL   RAELQEGARQ   KLHELQEKLS   100
101   PLGEEMRDRA   RAHVDALRTH   LAPYSDELRQ   RLAARLEALK   ENGGARLAEY   150
151   HAKATEHLST   LSEKAKPALE   DLRQGLLPVL   ESFKVSFLSA   LEEYTKKLNT   200
201   Q           250

Variants

Residue AA Source /
dbSNP		 Clinical
Significance
 Allele
Frequency
(> 0.0001)		 AlphaMissense
pathogenicity		 Disease name
50_TRP ARG ClinVar
chr11:116707108
rs121912726
Pathogenic - 0.9737 Familial amyloid polyneuropathy, Iowa type|not provided [MONDO:MONDO:0971008,MedGen:C4551500,OMIM:620657|MedGen:C3661900]
53_VAL MET 8.3kJPN
chr11:116707099
-
- 0.0006 0.1276 -
60_LEU ARG VAR_000610
rs121912724
LP/P - 0.9408 Amyloidosis, hereditary systemic 3 (AMYLD3) [MIM:620657]
60_LEU ARG ClinVar
chr11:116707077
rs121912724
Pathogenic - 0.9408 Familial amyloid polyneuropathy, Iowa type [MONDO:MONDO:0971008,MedGen:C4551500,OMIM:620657]
68_THR ILE VAR_017017
rs766422306
LB/B - 0.8768 -
71_PHE TYR gnomAD
chr11:116707044
rs138407155
- 0.000521099 0.4617 -
72_TRP ARG ClinVar
chr11:116707042
-
Pathogenic - - Familial amyloid polyneuropathy, Iowa type [MONDO:MONDO:0971008,MedGen:C4551500,OMIM:620657]
74_ASN LYS 8.3kJPN
chr11:116707034
-
- 0.0001 0.1751 -
75_LEU PRO ClinVar
chr11:116707032
rs372520221
Pathogenic/Likely pathogenic - 0.993 not provided|Cardiovascular phenotype|Hypoalphalipoproteinemia, primary, 2 [MedGen:C3661900|MedGen:CN230736|MONDO:MONDO:0032766,MedGen:C5551172,OMIM:618463]; Hypoalphalipoproteinemia, primary, 2, intermediate [MONDO:MONDO:0859238,MedGen:C5677030,OMIM:619836]; Familial amyloid polyneuropathy, Iowa type [MONDO:MONDO:0971008,MedGen:C4551500,OMIM:620657]
79_THR ILE 8.3kJPN
chr11:116707020
-
- 0.0001 0.8659 -
84_GLN TER ClinVar
chr11:116707006
rs121912723
Pathogenic - - Hypoalphalipoproteinemia, primary, 2 [MONDO:MONDO:0032766,MedGen:C5551172,OMIM:618463]
84_GLN TER 8.3kJPN
chr11:116707006
rs121912723
- 0.0001 - -
89_ASP GLU VAR_000611
rs150243849
LB/B - 0.6948 -
95_ALA ASP VAR_000612
-
US - 0.1819 -
95_ALA ASP 8.3kJPN
chr11:116706972
-
- 0.0002 0.1819 -
98_GLN TER ClinVar
chr11:116706964
rs2134231221
Likely pathogenic - - Hypoalphalipoproteinemia, primary, 2 [MONDO:MONDO:0032766,MedGen:C5551172,OMIM:618463]
102_ASP HIS VAR_016189
rs5077
LB/B - 0.3377 -
103_ASP ASN VAR_000613
rs921646982
LB/B - 0.098 -
107_LYS MET VAR_000615
rs4882
LB/B - 0.5307 -
107_LYS TER ClinVar
chr11:116706937
rs121912716
Pathogenic - - APOLIPOPROTEIN A-I (MARBURG) [-]
108_TRP ARG VAR_000616
-
US - 0.9757 -
110_GLU LYS VAR_000617
-
US - 0.1697 -
128_GLU LYS gnomAD
chr11:116706874
rs574061789
- 0.000203646 0.1906 -
136_GLU LYS VAR_000618
rs121912718
LB/B - 0.2602 -
136_GLU TER ClinVar
chr11:116706850
rs121912718
Pathogenic - - Hypoalphalipoproteinemia, primary, 2, intermediate [MONDO:MONDO:0859238,MedGen:C5677030,OMIM:619836]
139_GLU GLY VAR_000619
rs758509542
LB/B - 0.0769 -
141_LEU ARG ClinVar
chr11:116706834
rs779081481
Pathogenic - 0.9302 not provided [MedGen:C3661900]
143_PRO ARG VAR_000620
rs121912719
LB/B - 0.3946 -
144_LEU ARG VAR_000621
-
US - 0.4046 -
147_GLU VAL VAR_000622
rs1015066427
LB/B - 0.3252 -
149_ARG SER VAR_074073
-
US - 0.9238 -
149_ARG PRO VAR_083310
-
US - 0.9624 Amyloidosis, hereditary systemic 3 (AMYLD3) [MIM:620657]
149_ARG PRO ClinVar
chr11:116706810
rs387906571
Pathogenic - 0.9624 Familial amyloid polyneuropathy, Iowa type [MONDO:MONDO:0971008,MedGen:C4551500,OMIM:620657]
155_HIS ARG 8.3kJPN
chr11:116706792
rs1023694493
- 0.0002 0.3602 -
156_VAL GLU VAR_021362
rs121912727
LB/B - 0.9365 -
156_VAL GLU ClinVar
chr11:116706789
rs121912727
Pathogenic - 0.9365 Hypoalphalipoproteinemia, primary, 2 [MONDO:MONDO:0032766,MedGen:C5551172,OMIM:618463]
156_VAL GLU 8.3kJPN
chr11:116706789
rs121912727
- 0.0001 0.9365 -
157_ASP GLY ClinVar
chr11:116706786
rs2134230655
Likely pathogenic - 0.4491 Hypoalphalipoproteinemia, primary, 2 [MONDO:MONDO:0032766,MedGen:C5551172,OMIM:618463]
160_ARG PRO VAR_014609
rs5078
LB/B - 0.9805 -
164_ALA SER gnomAD
chr11:116706766
rs140770089
- 0.000497371 0.0918 -
165_PRO ARG VAR_000623
rs121912722
LB/B - 0.6776 -
173_ARG CYS VAR_000624
rs28931573
LB/B - 0.5481 -
173_ARG CYS ClinVar
chr11:116706739
rs28931573
Pathogenic - 0.5481 APOLIPOPROTEIN A-I (MILANO) [-]
173_ARG PRO ClinVar
chr11:116706738
rs121912728
Pathogenic - 0.7712 not provided [MedGen:C3661900]
174_LEU SER VAR_083311
-
LP/P - 0.9016 Amyloidosis, hereditary systemic 3 (AMYLD3) [MIM:620657]
174_LEU SER ClinVar
chr11:116706735
rs121912729
Pathogenic - 0.9016 Familial amyloid polyneuropathy, Iowa type [MONDO:MONDO:0971008,MedGen:C4551500,OMIM:620657]
175_ALA PRO VAR_083312
-
US - 0.8449 Amyloidosis, hereditary systemic 3 (AMYLD3) [MIM:620657]
175_ALA PRO ClinVar
chr11:116706733
rs121912730
Pathogenic - 0.8449 Familial amyloid polyneuropathy, Iowa type [MONDO:MONDO:0971008,MedGen:C4551500,OMIM:620657]
178_LEU PRO ClinVar
chr11:116706723
rs2134230434
Pathogenic - 0.938 not provided [MedGen:C3661900]
198_GLU LYS VAR_000625
rs121912717
LB/B - 0.1756 -
198_GLU LYS 8.3kJPN
chr11:116706664
rs121912717
- 0.0001 0.1756 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.