| PDB ID | 1ATR
|
CHAIN | A |
|---|---|---|---|
| Protein name | HEAT-SHOCK COGNATE 70 KD PROTEIN | ||
| Uniprot Accession | P19120 | ||
| The number of similar proteins | 73 | ||
| The number of binding states | 6 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1ATR (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
Q27974
|
| 3 |
Q91YN9
|
| 4 |
Q99933
|
| 5 |
Q0WUQ1
|
| 6 |
Q91YN9
Q91YN9
|
Downdload
Molecule viewer
|
Only interaction residues |
|
||||||||||
|
Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 2_ALA | VAL |
gnomAD chr14:65007575 rs138216816 |
- | 0.000342662 | - | - | |
| 6_ALA | PRO |
gnomAD chr6:31779728 rs9469057 |
- | 0.00760461 | - | - | |
| 6_ALA | THR |
gnomAD chr6:31779728 rs9469057 |
- | 0.000645336 | - | - | |
| 6_ALA | THR |
8.3kJPN chr6:31779728 rs9469057 |
- | - | - | - | |
| 7_ILE | VAL |
8.3kJPN chr14:65007589 - |
- | 0.0001 | - | - | |
| 11_LEU | PRO |
gnomAD chr1:161494486 rs762080859 |
- | 0.000231462 | - | - | |
| 11_LEU | VAL |
8.3kJPN chr1:161494485 - |
- | 0.0003 | - | - | |
| 18_VAL | MET |
gnomAD chr6:31783585 rs202172229 |
- | 0.000519447 | - | - | |
| 19_GLY | ARG |
8.3kJPN chr14:65007625 - |
- | 0.0001 | - | - | |
| 28_ILE | THR |
8.3kJPN chr1:161494537 - |
- | 0.0001 | - | - | |
| 31_ASN | SER |
gnomAD chr6:31779652 rs201814236 |
- | 0.000210757 | - | - | |
| 32_ASP | ASN |
8.3kJPN chr6:31779650 rs746628579 |
- | 0.0001 | - | - | |
| 35_ASN | SER |
8.3kJPN chr1:161494558 rs766366684 |
- | 0.0001 | - | - | |
| 36_ARG | HIS |
gnomAD chr6:31779637 rs373639301 |
- | 0.000330054 | - | - | |
| 39_PRO | THR |
gnomAD chr1:161494569 rs529535145 |
- | 0.000750683 | - | - | |
| 39_PRO | THR |
8.3kJPN chr1:161494569 rs529535145 |
- | 0.0001 | - | - | |
| 42_VAL | MET |
gnomAD chr6:31779620 rs189710538 |
- | 0.000425485 | - | - | |
| 42_VAL | MET |
8.3kJPN chr6:31779620 rs189710538 |
- | 0.0018 | - | - | |
| 51_ILE | THR |
gnomAD chr6:31779592 rs141349016 |
- | 0.000938422 | - | - | |
| 59_VAL | GLU |
8.3kJPN chr14:65007746 - |
- | 0.0001 | - | - | |
| 61_MET | VAL |
gnomAD chr14:65007751 rs140108798 |
- | 0.000457409 | - | - | |
| 63_PRO | THR |
8.3kJPN chr1:161494641 rs41297698 |
- | 0.0007 | - | - | |
| 67_VAL | MET |
8.3kJPN chr1:161494653 rs375370283 |
- | 0.0001 | - | - | |
| 72_ARG | CYS |
gnomAD chr6:31779530 rs145946517 |
- | 0.000314148 | - | - | |
| 74_ILE | MET |
8.3kJPN chr6:31783755 rs1043620 |
- | - | - | - | |
| 75_GLY | ALA |
gnomAD chr1:161494678 rs150647842 |
- | 0.000181345 | - | - | |
| 75_GLY | SER |
8.3kJPN chr6:31779521 rs368138379 |
- | 0.0001 | - | - | |
| 91_PRO | SER |
8.3kJPN chr1:161494725 - |
- | 0.0001 | - | - | |
| 91_PRO | LEU |
8.3kJPN chr6:31779472 rs199562102 |
- | 0.0018 | - | - | |
| 93_ARG | GLY |
gnomAD chr1:161494731 rs201325536 |
- | 0.0021557 | - | - | |
| 93_ARG | GLN |
8.3kJPN chr1:161494732 rs400835 |
- | 0.0006 | - | - | |
| 98_GLY | GLU |
8.3kJPN chr6:31779451 - |
- | 0.0001 | - | - | |
| 103_VAL | LEU |
gnomAD chr1:161494761 rs140716677 |
- | 0.000100042 | - | - | |
| 106_CYS | TYR |
8.3kJPN chr1:161494771 - |
- | 0.0001 | - | - | |
| 108_ARG | CYS |
8.3kJPN chr1:161494776 rs368369664 |
- | 0.0001 | - | - | |
| 110_GLU | ASP |
gnomAD chr6:31783863 rs562047 |
- | 0.15785 | - | - | |
| 110_GLU | ASP |
gnomAD chr6:31796057 rs144223778 |
- | 0.0579029 | - | - | |
| 110_GLU | ASP |
8.3kJPN chr6:31783863 rs562047 |
- | 0.0536 | - | - | |
| 110_GLU | ASP |
8.3kJPN chr6:31796057 rs144223778 |
- | 0.053 | - | - | |
| 111_ASP | GLU |
8.3kJPN chr1:161494787 - |
- | 0.0001 | - | - | |
| 111_THR | ALA |
8.3kJPN chr11:122931381 - |
- | 0.0001 | - | - | |
| 113_ALA | VAL |
8.3kJPN chr6:31783871 - |
- | 0.0001 | - | - | |
| 116_PRO | LEU |
8.3kJPN chr6:31779397 rs1339887302 |
- | 0.0001 | - | - | |
| 119_ILE | VAL |
8.3kJPN chr1:161494809 rs772752500 |
- | 0.0001 | - | - | |
| 129_GLU | ASP |
8.3kJPN chr6:31779357 - |
- | 0.0001 | - | - | |
| 132_GLU | LYS |
gnomAD chr6:31796121 rs1406810342 |
- | 0.000110448 | - | - | |
| 135_LEU | VAL |
8.3kJPN chr1:161494857 - |
- | 0.0001 | - | - | |
| 138_PRO | SER |
gnomAD chr6:31796139 rs1414774525 |
- | 0.000129938 | - | - | |
| 140_THR | SER |
8.3kJPN chr11:122930969 rs141156763 |
- | 0.0018 | - | - | |
| 146_VAL | MET |
8.3kJPN chr1:161494890 rs373442940 |
- | 0.0001 | - | - | |
| 146_VAL | GLU |
8.3kJPN chr1:161494891 - |
- | 0.0001 | - | - | |
| 151_ASN | SER |
gnomAD chr1:161494906 rs10919225 |
- | 0.00231426 | - | - | |
| 151_ASN | SER |
8.3kJPN chr6:31779292 rs775085801 |
- | 0.0001 | - | - | |
| 152_ASP | ASN |
gnomAD chr1:161494908 rs10919226 |
- | 0.00231898 | - | - | |
| 155_ARG | SER |
8.3kJPN chr6:31779281 rs202165632 |
- | 0.0006 | - | - | |
| 157_ALA | VAL |
gnomAD chr1:161494924 rs41297702 |
- | 0.000115939 | - | - | |
| 158_THR | ILE |
gnomAD chr6:31784006 rs1246559171 |
- | 0.00011217 | - | - | |
| 162_GLY | CYS |
8.3kJPN chr14:65008054 - |
- | 0.0001 | - | - | |
| 171_ARG | TRP |
8.3kJPN chr1:161494965 rs775207128 |
- | 0.0001 | - | - | |
| 174_ASN | SER |
8.3kJPN chr6:31779223 rs761403757 |
- | 0.0001 | - | - | |
| 177_THR | MET |
8.3kJPN chr1:161494984 rs376584149 |
- | 0.0001 | - | - | |
| 181_ILE | VAL |
8.3kJPN chr1:161494995 rs777795960 |
- | 0.0001 | - | - | |
| 181_ILE | VAL |
8.3kJPN chr11:122930847 - |
- | 0.0001 | - | - | |
| 186_ASP | GLY |
8.3kJPN chr1:161495011 - |
- | 0.0001 | - | - | |
| 187_ARG | GLN |
8.3kJPN chr1:161495014 rs1057428989 |
- | - | - | - | |
| 188_THR | ARG |
gnomAD chr6:31796290 rs1222040287 |
- | 0.000272377 | - | - | |
| 192_GLU | LYS |
gnomAD chr1:161495028 rs41297714 |
- | 0.000139635 | - | - | |
| 192_GLU | LYS |
8.3kJPN chr1:161495028 rs41297714 |
- | 0.0054 | - | - | |
| 193_ARG | GLN |
gnomAD chr6:31779166 rs201198988 |
- | 0.000974295 | - | - | |
| 193_ARG | TER |
8.3kJPN chr6:31779167 rs770917469 |
- | 0.0001 | - | - | |
| 195_VAL | MET |
gnomAD chr1:161495037 rs139552185 |
- | 0.00018727 | - | - | |
| 196_LEU | PHE |
gnomAD chr1:161495040 rs1079109 |
- | 0.118177 | - | - | |
| 196_LEU | PHE |
8.3kJPN chr1:161495040 rs1079109 |
- | 0.2291 | - | - | |
| 199_ASP | TYR |
8.3kJPN chr6:31779149 rs373875697 |
- | 0.0001 | - | - | |
| 204_THR | ILE |
gnomAD chr1:161495065 rs149827217 |
- | 0.000258713 | - | - | |
| 207_VAL | MET |
8.3kJPN chr6:31779125 rs781761072 |
- | 0.0001 | - | - | |
| 219_VAL | ILE |
gnomAD chr6:31779089 rs150472288 |
- | 0.000777469 | - | - | |
| 225_ASP | ASN |
gnomAD chr6:31784206 rs1339464388 |
- | 0.00270479 | - | - | |
| 232_ASP | ASN |
gnomAD chr1:161495148 rs147002100 |
- | 0.000146966 | - | - | |
| 238_VAL | MET |
8.3kJPN chr14:65008288 - |
- | 0.0001 | - | - | |
| 242_ALA | VAL |
8.3kJPN chr14:65008301 rs770917203 |
- | 0.0004 | - | - | |
| 256_ASN | ILE |
8.3kJPN chr14:65008343 - |
- | 0.0001 | - | - | |
| 261_ARG | HIS |
8.3kJPN chr1:161495236 - |
- | - | - | - | |
| 265_THR | ALA |
8.3kJPN chr6:31778951 rs769994484 |
- | 0.0017 | - | - | |
| 266_ALA | THR |
gnomAD chr6:31778948 rs34620296 |
- | 0.00490996 | - | - | |
| 266_ALA | THR |
8.3kJPN chr6:31778948 rs34620296 |
- | 0.002 | - | - | |
| 269_ARG | GLY |
gnomAD chr6:31796532 rs1414260858 |
- | 0.000125597 | - | - | |
| 270_ALA | THR |
8.3kJPN chr1:161495262 - |
- | 0.0001 | - | - | |
| 270_ALA | VAL |
8.3kJPN chr1:161495263 - |
- | 0.0001 | - | - | |
| 272_ARG | LEU |
8.3kJPN chr1:161495269 - |
- | 0.0001 | - | - | |
| 273_THR | SER |
8.3kJPN chr14:65008393 - |
- | 0.0001 | - | - | |
| 274_LEU | PRO |
8.3kJPN chr1:161495275 rs200790521 |
- | 0.1267 | - | - | |
| 281_ASN | ASP |
8.3kJPN chr6:31778903 rs754506860 |
- | 0.0001 | - | - | |
| 282_ILE | MET |
8.3kJPN chr14:65008422 - |
- | 0.0001 | - | - | |
| 292_ASP | GLY |
gnomAD chr6:31778869 rs34360259 |
- | 0.000119414 | - | - | |
| 292_ASP | GLY |
8.3kJPN chr6:31778869 rs34360259 |
- | 0.0104 | - | - | |
| 293_PHE | SER |
gnomAD chr1:161495332 rs543491153 |
- | 0.000642797 | - | - | |
| 294_TYR | HIS |
8.3kJPN chr1:161495334 - |
- | 0.0002 | - | - | |
| 295_THR | MET |
gnomAD chr6:31796611 rs1291288994 |
- | 0.000140647 | - | - | |
| 295_THR | LYS |
8.3kJPN chr1:161495338 rs41297718 |
- | 0.1629 | - | - | |
| 295_THR | ILE |
8.3kJPN chr11:122930417 rs763133730 |
- | 0.0001 | - | - | |
| 297_ILE | PHE |
8.3kJPN chr6:31778855 - |
- | 0.0001 | - | - | |
| 304_GLU | LYS |
gnomAD chr1:161495364 rs748365478 |
- | 0.000112116 | - | - | |
| 306_CYS | TYR |
8.3kJPN chr1:161495371 - |
- | 0.0002 | - | - | |
| 308_ASP | HIS |
8.3kJPN chr1:161495376 rs529246286 |
- | 0.0044 | - | - | |
| 322_ARG | GLN |
gnomAD chr6:31778779 rs142398035 |
- | 0.000103412 | - | - | |
| 332_HIS | GLN |
gnomAD chr6:31796723 rs1474071038 |
- | 0.000148412 | - | - | |
| 334_VAL | PHE |
gnomAD chr1:161495454 rs417707 |
- | 0.000222932 | - | - | |
| 337_VAL | MET |
gnomAD chr1:161495463 rs142859332 |
- | 0.00284643 | - | - | |
| 338_GLY | ARG |
8.3kJPN chr1:161495466 - |
- | 0.0001 | - | - | |
| 339_GLY | ASP |
gnomAD chr1:161495470 rs138329594 |
- | 0.000139366 | - | - | |
| 339_GLY | SER |
8.3kJPN chr6:31778729 - |
- | 0.0001 | - | - | |
| 348_LYS | ARG |
gnomAD chr1:161495497 rs144853604 |
- | 0.000580274 | - | - | |
| 360_ASN | LYS |
gnomAD chr6:31784613 rs1313269531 |
- | 0.00052573 | - | - | |
| 362_SER | ASN |
8.3kJPN chr1:161495539 rs768447503 |
- | 0.0001 | - | - | |
| 373_ALA | SER |
8.3kJPN chr1:161495571 rs9659608 |
- | 0.2275 | - | - | |
| 383_ASP | ASN |
8.3kJPN chr1:161495601 rs746948130 |
- | 0.0001 | - | - |