| PDB ID | 1ARL
|
CHAIN | A |
|---|---|---|---|
| Protein name | APO-CARBOXYPEPTIDASE A=ALPHA= (COX) | ||
| Uniprot Accession | P00730 | ||
| The number of similar proteins | 39 | ||
| The number of binding states | 7 | ||
| The number of binding partners | 6 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1ARL (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
58374130
|
| 3 |
P00730
|
| 4 |
P01075
|
| 5 |
P00730
P00730
|
| 6 |
1PYT
P00730
|
| 7 |
P00730
P81511
P81511
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 5_ASP | ASN |
8.3kJPN chr7:130021666 rs782573440 |
- | 0.0008 | - | - | |
| 14_THR | ILE |
gnomAD chr7:130021694 rs150653308 |
- | 0.00186315 | - | - | |
| 27_ALA | GLY |
gnomAD chr7:130021977 rs183429188 |
- | 0.000183007 | - | - | |
| 27_ALA | GLY |
8.3kJPN chr7:130021977 rs183429188 |
- | 0.0024 | - | - | |
| 30_PRO | ARG |
8.3kJPN chr7:130021986 - |
- | 0.0005 | - | - | |
| 54_THR | MET |
8.3kJPN chr7:130023239 rs781903028 |
- | 0.0001 | - | - | |
| 56_GLY | ASP |
gnomAD chr7:130023245 rs144546424 |
- | 0.00171453 | - | - | |
| 59_ARG | HIS |
gnomAD chr7:130023254 rs114365673 |
- | 0.000334648 | - | - | |
| 59_ARG | HIS |
8.3kJPN chr7:130023254 rs114365673 |
- | 0.0001 | - | - | |
| 71_ARG | GLN |
8.3kJPN chr7:130023290 rs377042960 |
- | 0.0001 | - | - | |
| 92_GLN | LYS |
gnomAD chr7:130023543 rs61735962 |
- | 0.0011059 | - | - | |
| 98_ALA | THR |
gnomAD chr7:130023561 rs34474469 |
- | 0.0260035 | - | - | |
| 110_VAL | ILE |
8.3kJPN chr7:130023597 - |
- | 0.0002 | - | - | |
| 146_ASN | LYS |
ClinVar chr7:130024448 rs1796449608 |
Likely pathogenic | - | - | not provided [MedGen:C3661900] | |
| 159_ASN | LYS |
8.3kJPN chr7:130025006 rs782284797 |
- | 0.0001 | - | - | |
| 160_PRO | LEU |
8.3kJPN chr7:130025008 - |
- | 0.0001 | - | - | |
| 172_SER | PRO |
ClinVar chr7:130025043 - |
Likely pathogenic | - | - | not provided [MedGen:C3661900] | |
| 231_ALA | THR |
gnomAD chr7:130025713 rs77792157 |
- | 0.000183034 | - | - | |
| 231_ALA | THR |
8.3kJPN chr7:130025713 rs77792157 |
- | 0.0569 | - | - | |
| 252_GLY | GLU |
ClinVar chr7:130027677 rs2117509052 |
Likely pathogenic | - | - | not provided [MedGen:C3661900] | |
| 255_ILE | THR |
8.3kJPN chr7:130027686 - |
- | 0.0001 | - | - | |
| 272_ARG | GLN |
8.3kJPN chr7:130027737 rs782284762 |
- | 0.0001 | - | - | |
| 276_ARG | CYS |
gnomAD chr7:130027748 rs201750163 |
- | 0.000131252 | - | - | |
| 276_ARG | CYS |
8.3kJPN chr7:130027748 rs201750163 |
- | 0.0001 | - | - | |
| 293_THR | MET |
8.3kJPN chr7:130027800 rs141400125 |
- | 0.0001 | - | - |