PiSITE

PDB ID	1AML	CHAIN	A
Protein name	AMYLOID A4
Uniprot Accession	P05067
The number of similar proteins	218
The number of binding states	17
The number of binding partners	7

Binding state	Binding partners
	1AML (CHAIN: A)
1	Monomeric state
2	P05067
3	P14735
4	P80188
5	Q5JRX3
6	P05067 P05067
7	2OTK 2OTK
8	3IFN 3IFN
9	P05067 P05067 P05067
10	P05067 P05067 P05067 P05067
11	P05067 P05067 P05067 P05067 P05067
12	P05067 P05067 P05067 P05067 P05067 P05067
13	P05067 P05067 P05067 P05067 P05067 P05067 P05067
14	P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067
15	P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067
16	P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067
17	P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067 P05067

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Only interaction residues

#binding
partners

	5
	4
	3
	2
	1
	0

Sequence information

1

DAEFRHDSGY

EVHHQKLVFF

AEDVGSNKGA

IIGLMVGGVV

50

Binding partner information

P05067

Amyloid beta A4 protein

Binding partner information

P14735

INSULIN DEGRADING ENZYME

Binding partner information

P80188

Neutrophil gelatinase-associated lipocalin

Binding partner information

Q5JRX3

Presequence protease, mitochondrial

Binding partner information

	P05067	Amyloid beta A4 protein
	P05067	Amyloid beta A4 protein

Binding partner information

	2OTK	ZAb3 Affibody dimer
	2OTK	ZAb3 Affibody dimer

Binding partner information

	3IFN	12A11 FAB antibody light chain
	3IFN	12A11 FAB antibody heavy chain

Binding partner information

	P05067	Amyloid beta A4 protein
	P05067	Amyloid beta A4 protein
	P05067	Amyloid beta A4 protein

Binding partner information

	P05067	Beta-amyloid protein 42
	P05067	Beta-amyloid protein 42
	P05067	Beta-amyloid protein 42
	P05067	Beta-amyloid protein 42

Binding partner information

	P05067	Beta-amyloid protein 42
	P05067	Beta-amyloid protein 42
	P05067	Beta-amyloid protein 42
	P05067	Beta-amyloid protein 42
	P05067	Beta-amyloid protein 42

Binding partner information

	P05067	Beta-amyloid protein 42
	P05067	Beta-amyloid protein 42
	P05067	Beta-amyloid protein 42
	P05067	Beta-amyloid protein 42
	P05067	Beta-amyloid protein 42
	P05067	Beta-amyloid protein 42

Binding partner information

	P05067	Amyloid-beta precursor protein
	P05067	Amyloid-beta precursor protein
	P05067	Amyloid-beta precursor protein
	P05067	Amyloid-beta precursor protein
	P05067	Amyloid-beta precursor protein
	P05067	Amyloid-beta precursor protein
	P05067	Amyloid-beta precursor protein

Binding partner information

	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40

Binding partner information

	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40
	P05067	Beta-amyloid protein 40

Binding partner information

Variants

Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
2_ALA	VAL	ClinVar chr21:27269931 rs193922916	Pathogenic	-	0.1348	Alzheimer disease [Human Phenotype Ontology:HP:0002511,Human Phenotype Ontology:HP:0006878,Human Phenotype Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020]
2_ALA	THR	gnomAD chr21:27269932 rs63750847	-	0.000445519	0.0709	-
7_ASP	ASN	VAR_044424 rs63750064	LP/P	-	0.1047	Alzheimer disease 1 (AD1) [MIM:104300]
7_ASP	HIS	ClinVar chr21:27269917 rs63750064	Likely pathogenic	-	0.2073	not provided [MedGen:CN517202]
13_HIS	LEU	8.3kJPN chr21:27269898 -	-	0.0001	0.1812	-
16_LYS	ASN	ClinVar chr21:27269888 -	Likely pathogenic	-	0.7779	Cerebral amyloid angiopathy, APP-related [MONDO:MONDO:0011583,MedGen:C2751536,OMIM:605714,Orphanet:100006,Orphanet:324703,Orphanet:324708,Orphanet:324713,Orphanet:324718,Orphanet:324723,Orphanet:85458]; Alzheimer disease type 1 [MONDO:MONDO:0007088,MedGen:C1863052,OMIM:104300]
20_PHE	LEU	8.3kJPN chr21:27264174 -	-	0.0001	0.7713	-
21_ALA	GLY	VAR_000016 rs63750671	LP/P	-	0.2623	Alzheimer disease 1 (AD1) [MIM:104300]
21_ALA	GLY	ClinVar chr21:27264170 rs63750671	Pathogenic	-	0.2623	Alzheimer disease type 1\|Alzheimer disease\|ABetaA21G amyloidosis\|not provided [MONDO:MONDO:0007088,MedGen:C1863052,OMIM:104300\|Human Phenotype Ontology:HP:0002511,Human Phenotype Ontology:HP:0006878,Human Phenotype Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020\|MONDO:MONDO:0017948,MedGen:C3888307,Orphanet:324718\|MedGen:C3661900]
22_GLU	GLN	VAR_000017 rs63750579	LP/P	-	0.3223	Cerebral amyloid angiopathy, APP-related (CAA-APP) [MIM:605714]
22_GLU	GLY	VAR_014215 rs63751039	LP/P	-	0.375	Alzheimer disease 1 (AD1) [MIM:104300]
22_GLU	LYS	VAR_014216 rs63750579	LP/P	-	0.4093	Cerebral amyloid angiopathy, APP-related (CAA-APP) [MIM:605714]
22_GLU	GLN	ClinVar chr21:27264168 rs63750579	Pathogenic	-	0.3223	ABeta amyloidosis, dutch type\|Cerebral amyloid angiopathy, APP-related\|Alzheimer disease [MONDO:MONDO:0015033,MedGen:C2931672,Orphanet:100006\|MONDO:MONDO:0011583,MedGen:C2751536,OMIM:605714,Orphanet:100006,Orphanet:324703,Orphanet:324708,Orphanet:324713,Orphanet:324718,Orphanet:324723,Orphanet:85458\|Human Phenotype Ontology:HP:0002511,Human Phenotype Ontology:HP:0006878,Human Phenotype Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020]
22_GLU	GLY	ClinVar chr21:27264167 rs63751039	Pathogenic	-	0.375	Alzheimer disease type 1\|ABeta amyloidosis, Arctic type\|Alzheimer disease\|not provided [MONDO:MONDO:0007088,MedGen:C1863052,OMIM:104300\|MONDO:MONDO:0017949,MedGen:C2751494,Orphanet:324723\|Human Phenotype Ontology:HP:0002511,Human Phenotype Ontology:HP:0006878,Human Phenotype Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020\|MedGen:C3661900]
22_GLU	LYS	ClinVar chr21:27264168 rs63750579	Pathogenic	-	0.4093	ABeta amyloidosis, Italian type\|not provided [MONDO:MONDO:0017947,MedGen:C3888308,Orphanet:324713\|MedGen:CN517202]
23_ASP	ASN	VAR_014217 rs63749810	LP/P	-	0.2397	Cerebral amyloid angiopathy, APP-related (CAA-APP) [MIM:605714]
23_ASP	ASN	ClinVar chr21:27264165 rs63749810	Pathogenic	-	0.2397	ABeta amyloidosis, Iowa type\|not provided\|Alzheimer disease [MONDO:MONDO:0017946,MedGen:C3888309,Orphanet:324708\|MedGen:C3661900\|Human Phenotype Ontology:HP:0002511,Human Phenotype Ontology:HP:0006878,Human Phenotype Ontology:HP:0007213,MONDO:MONDO:0004975,MeSH:D000544,MedGen:C0002395,Orphanet:1020]
24_VAL	MET	8.3kJPN chr21:27264162 -	-	0.0001	0.1176	-
34_LEU	VAL	VAR_032276 rs63750921	LP/P	-	0.5576	Cerebral amyloid angiopathy, APP-related (CAA-APP) [MIM:605714]
34_LEU	VAL	ClinVar chr21:27264132 rs63750921	Pathogenic	-	0.5576	CEREBRAL AMYLOID ANGIOPATHY, APP-RELATED, PIEDMONT VARIANT\|not provided [\|MedGen:CN517202]

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Variants

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