PDB ID 1AK8     CHAIN A
Protein name CALMODULIN
Uniprot Accession P62157
The number of similar proteins 22
The number of binding states 5
The number of binding partners 4

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1AK8 (CHAIN: A)
1 Monomeric state
2 Q9QUQ5  
3 P62158  
4 Q9QXS1  
5 C6SUZ2   P19334  

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Format:

Molecule viewer


Only interaction residues
#binding
partners
  4
  3
  2
  1
  0

Sequence information

1   MADQLTEEQI   AEFKEAFSLF   DKDGDGTITT   KELGTVMRSL   GQNPTEAELQ   50
51   DMINEVDADG   NGTIDFPEFL   TMMARK       100

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
23_GLY GLU 8.3kJPN
chr10:5567119 		-
- 0.0001 -
29_THR PRO ClinVar
chr14:90867656 		rs1057521851
Likely pathogenic - not provided [MedGen:CN517202]
29_THR SER 8.3kJPN
chr10:5567136 		-
- 0.0001 -
31_GLU GLN gnomAD
chr10:5567142 		rs2231420
- 0.00532811 -
31_GLU GLN 8.3kJPN
chr10:5567142 		rs2231420
- 0.0341 -
51_MET VAL 8.3kJPN
chr10:5567202 		-
- 0.0001 -
53_ASN ILE ClinVar
chr14:90867729 		rs267607276
Likely pathogenic - Catecholaminergic polymorphic ventricular tachycardia 4|Catecholaminergic polymorphic ventricular tachycardia 1 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286|MONDO:MONDO:0011484,MedGen:C1631597,OMIM:604772,Orphanet:3286]
61_GLY SER gnomAD
chr10:5567232 		rs550418190
- 0.000502304 -
66_PRO SER gnomAD
chr10:5567247 		rs75808734
- 0.000394542 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.