| PDB ID | 1AK8
|
CHAIN | A |
|---|---|---|---|
| Protein name | CALMODULIN | ||
| Uniprot Accession | P62157 | ||
| The number of similar proteins | 22 | ||
| The number of binding states | 5 | ||
| The number of binding partners | 4 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1AK8 (CHAIN: A) | |
| 1 | Monomeric state |
| 2 |
Q9QUQ5
|
| 3 |
P62158
|
| 4 |
Q9QXS1
|
| 5 |
C6SUZ2
P19334
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 23_GLY | GLU |
8.3kJPN chr10:5567119 - |
- | 0.0001 | - | - | |
| 29_THR | PRO |
ClinVar chr14:90867656 rs1057521851 |
Likely pathogenic | - | - | not provided [MedGen:CN517202] | |
| 29_THR | SER |
8.3kJPN chr10:5567136 - |
- | 0.0001 | - | - | |
| 31_GLU | GLN |
gnomAD chr10:5567142 rs2231420 |
- | 0.00532811 | - | - | |
| 31_GLU | GLN |
8.3kJPN chr10:5567142 rs2231420 |
- | 0.0341 | - | - | |
| 51_MET | VAL |
8.3kJPN chr10:5567202 - |
- | 0.0001 | - | - | |
| 53_ASN | ILE |
ClinVar chr14:90867729 rs267607276 |
Likely pathogenic | - | - | Catecholaminergic polymorphic ventricular tachycardia 4|Catecholaminergic polymorphic ventricular tachycardia 1 [MONDO:MONDO:0013966,MedGen:C3554047,OMIM:614916,Orphanet:3286|MONDO:MONDO:0011484,MedGen:C1631597,OMIM:604772,Orphanet:3286] | |
| 61_GLY | SER |
gnomAD chr10:5567232 rs550418190 |
- | 0.000502304 | - | - | |
| 66_PRO | SER |
gnomAD chr10:5567247 rs75808734 |
- | 0.000394542 | - | - |