PiSITE

PDB ID	1AK4	CHAIN	A
Protein name	CYCLOPHILIN A
Uniprot Accession	P62937
The number of similar proteins	196
The number of binding states	9
The number of binding partners	6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding state	Binding partners
	1AK4 (CHAIN: A)
1	Q72497
2	Monomeric state
3	P01116
4	2XGY
5	P05092
6	P63098 Q08209
7	P62937 P62937
8	P63098 P63098 Q08209 Q08209
9	P62937 P62937 P62937 P62937

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Only interaction residues

#binding
partners

	5
	4
	3
	2
	1
	0

Sequence information

MVNPTVFFDI

AVDGEPLGRV

SFELFADKVP

KTAENFRALS

TGEKGFGYKG

SCFHRIIPGF

MCQGGDFTRH

NGTGGKSIYG

EKFEDENFIL

KHTGPGILSM

100

101

ANAGPNTNGS

QFFICTAKTE

WLDGKHVVFG

KVKEGMNIVE

AMERFGSRNG

150

151

KTSKKITIAD

CGQLE

200

Variants

Residue	AA	Source / dbSNP	Clinical Significance	Allele Frequency (> 0.0001)	AlphaMissense pathogenicity	Disease name
1_MET	THR	8.3kJPN chr1:143767847 -	-	0.0001	0.3805	-
1_MET	VAL	8.3kJPN chr1:143767848 -	-	0.0001	0.0873	-
5_VAL	ALA	8.3kJPN chr1:147955331 rs1553321610	-	0.0001	-	-
6_ILE	VAL	gnomAD chr1:143767833 rs7521153	-	0.107911	-	-
6_ILE	VAL	8.3kJPN chr1:143767833 rs1553321608	-	0.5	-	-
9_GLU	ASP	gnomAD chr1:148202435 rs782276145	-	0.00490196	-	-
12_VAL	ILE	gnomAD chr1:147955311 rs587649576	-	0.000381001	0.1152	-
12_VAL	ILE	8.3kJPN chr1:143767815 rs587775476	-	0.0004	0.1152	-
15_LYS	THR	gnomAD chr1:148202418 -	-	0.0174419	-	-
17_LEU	SER	8.3kJPN chr1:143767799 -	-	0.0001	0.5957	-
20_ILE	SER	8.3kJPN chr1:148202403 -	-	0.0001	-	-
20_ILE	VAL	8.3kJPN chr1:148202404 -	-	0.0001	-	-
22_ILE	THR	gnomAD chr1:143767784 rs199726441	-	0.000367662	-	-
23_LYS	GLU	8.3kJPN chr1:143767782 rs782571429	-	0.0001	-	-
24_GLN	LEU	gnomAD chr1:143767778 rs6604516	-	0.110676	-	-
24_GLN	LEU	8.3kJPN chr1:143767778 rs1553321587	-	0.5	-	-
24_LEU	GLN	8.3kJPN chr1:148202391 rs1310895899	-	0.0001	0.9912	-
26_ALA	SER	8.3kJPN chr1:143767773 rs1556172662	-	0.0009	0.1222	-
30_LEU	PRO	gnomAD chr1:144364083 -	-	0.5	-	-
30_LEU	PRO	gnomAD chr1:147955256 rs199950315	-	0.00167239	-	-
30_PRO	LEU	gnomAD chr1:148202373 -	-	0.00281215	0.8568	-
30_LEU	PRO	gnomAD chr1:149553166 -	-	0.435897	-	-
30_LEU	PRO	8.3kJPN chr1:144364083 rs1553277153	-	0.26	-	-
30_LEU	PRO	8.3kJPN chr1:147955256 rs199950315	-	0.1558	-	-
31_LYS	ASN	gnomAD chr1:143767756 rs201142708	-	0.000956015	0.8326	-
31_LYS	ASN	8.3kJPN chr1:143767756 -	-	0.0001	0.8326	-
33_ALA	GLU	8.3kJPN chr1:147955247 -	-	0.0001	0.9751	-
37_ARG	HIS	8.3kJPN chr1:143767739 rs587696524	-	0.0001	0.495	-
37_ARG	HIS	8.3kJPN chr1:148202352 rs1179581919	-	0.0004	0.495	-
40_SER	ASN	gnomAD chr1:148202343 -	-	0.00275229	0.8105	-
40_SER	ARG	8.3kJPN chr1:143767729 -	-	0.0001	0.9912	-
47_ARG	CYS	8.3kJPN chr1:143767710 rs267597992	-	0.0002	-	-
47_ARG	HIS	8.3kJPN chr1:148202322 rs1450763932	-	0.0001	-	-
47_ARG	HIS	8.3kJPN chr1:149553217 rs1385929705	-	0.0011	-	-
50_GLY	ALA	8.3kJPN chr7:44839039 -	-	0.0001	0.4972	-
64_GLY	VAL	8.3kJPN chr1:147955154 -	-	0.0005	0.9916	-
65_GLY	CYS	gnomAD chr1:147955152 rs782191172	-	0.000107365	0.994	-
65_GLY	ASP	gnomAD chr1:148202268 -	-	0.00288684	0.997	-
65_GLY	SER	8.3kJPN chr1:143767656 rs1556172429	-	0.0002	0.9912	-
68_THR	ILE	gnomAD chr1:143767646 rs148974023	-	0.0181706	0.8583	-
68_THR	ILE	gnomAD chr1:148202259 -	-	0.000674764	0.8583	-
68_THR	LYS	8.3kJPN chr1:147955142 -	-	0.0003	0.9251	-
69_HIS	TYR	gnomAD chr1:143767644 rs370416528	-	0.000142119	-	-
69_ARG	CYS	gnomAD chr1:147955140 rs587632258	-	0.000623025	0.2519	-
69_ARG	HIS	gnomAD chr1:148202256 -	-	0.101163	0.1639	-
69_HIS	ARG	8.3kJPN chr1:143767643 rs1553321535	-	0.4917	-	-
69_HIS	TYR	8.3kJPN chr1:143767644 rs370416528	-	0.1097	-	-
69_ARG	CYS	8.3kJPN chr1:144363967 -	-	0.0019	0.2519	-
69_ARG	CYS	8.3kJPN chr1:147955140 rs587632258	-	0.0003	0.2519	-
69_ARG	CYS	8.3kJPN chr7:44839316 rs759569570	-	0.0001	0.2519	-
70_HIS	PRO	gnomAD chr1:144363963 -	-	0.5	0.8663	-
70_HIS	PRO	gnomAD chr1:147955136 rs372484895	-	0.00156328	0.8663	-
70_PRO	HIS	gnomAD chr1:148202253 -	-	0.0427019	-	-
70_HIS	PRO	gnomAD chr1:149553286 -	-	0.5	0.8663	-
70_HIS	PRO	8.3kJPN chr1:144363963 rs1556598650	-	0.0092	0.8663	-
70_PRO	HIS	8.3kJPN chr1:148202253 rs1300338652	-	0.0002	-	-
72_GLY	ASP	gnomAD chr1:147955130 rs587684299	-	0.00142734	0.998	-
72_GLY	CYS	8.3kJPN chr1:148202248 -	-	0.0001	0.9929	-
73_THR	ALA	8.3kJPN chr1:148202245 rs1275248152	-	0.0001	0.7522	-
74_GLY	SER	gnomAD chr1:143767629 rs12407726	-	0.00901967	0.9577	-
74_GLY	ASP	gnomAD chr1:147955124 rs782544194	-	0.000115048	0.9935	-
74_GLY	ASP	gnomAD chr1:148202241 rs201764814	-	0.00340716	0.9935	-
74_GLY	ASP	8.3kJPN chr1:143767628 rs1553321523	-	0.4434	0.9935	-
74_GLY	SER	8.3kJPN chr1:143767629 rs1553321527	-	0.0002	0.9577	-
74_GLY	ASP	8.3kJPN chr1:148202241 rs201764814	-	0.0081	0.9935	-
75_ASP	GLU	gnomAD chr1:143767624 rs587732257	-	0.000160999	-	-
75_ASP	GLU	8.3kJPN chr1:143767624 rs587732257	-	0.0004	-	-
76_LYS	GLU	8.3kJPN chr1:143767623 rs782483473	-	0.0001	0.511	-
80_GLY	TRP	8.3kJPN chr1:148202224 rs1283212414	-	0.0011	0.9741	-
85_ASP	ASN	gnomAD chr1:147955092 -	-	0.000119457	0.9683	-
85_ASP	ASN	8.3kJPN chr1:147955092 rs1553321503	-	0.0001	0.9683	-
88_LEU	ILE	8.3kJPN chr1:143767587 rs1556172248	-	0.0001	-	-
90_ARG	TER	8.3kJPN chr1:143767581 rs782007857	-	0.0001	-	-
90_ARG	TER	8.3kJPN chr1:147955077 rs1346295031	-	0.0001	-	-
94_GLY	ALA	gnomAD chr1:143767568 rs377521864	-	0.00100786	0.395	-
94_GLY	SER	gnomAD chr1:143767569 rs587598335	-	0.00110918	0.4216	-
94_GLY	VAL	8.3kJPN chr1:143767568 rs377521864	-	-	0.7025	-
94_GLY	SER	8.3kJPN chr1:143767569 rs587598335	-	0.0001	0.4216	-
97_ILE	PHE	8.3kJPN chr1:143767560 rs781805323	-	0.0001	0.6448	-
98_LEU	PHE	gnomAD chr1:147955051 -	-	0.000121489	0.9739	-
98_LEU	TER	8.3kJPN chr1:147955052 -	-	0.0001	-	-
101_ALA	VAL	8.3kJPN chr1:143767547 rs1553321483	-	0.4823	0.9968	-
101_ALA	VAL	8.3kJPN chr1:144363870 -	-	0.0238	0.9968	-
101_ALA	VAL	8.3kJPN chr1:148202160 rs781828336	-	0.0021	0.9968	-
102_ASN	ILE	gnomAD chr1:143767544 rs781911564	-	0.0016785	0.9885	-
106_ASN	SER	8.3kJPN chr1:147955028 -	-	0.0001	0.1588	-
108_ASN	SER	gnomAD chr1:148202139 -	-	0.0842391	0.8018	-
108_ASN	SER	8.3kJPN chr1:148202139 rs1469676804	-	0.0004	0.8018	-
112_PHE	LEU	8.3kJPN chr1:143767513 rs1553321469	-	0.4885	0.9987	-
112_PHE	LEU	8.3kJPN chr1:144363836 -	-	0.0427	0.9987	-
112_PHE	LEU	8.3kJPN chr1:148202126 rs1553648642	-	0.0009	0.9987	-
115_CYS	PHE	8.3kJPN chr1:143767505 rs1556171913	-	0.0002	0.9885	-
116_THR	ASN	8.3kJPN chr1:143767502 -	-	0.0001	0.7802	-
116_ALA	THR	8.3kJPN chr1:144363826 -	-	0.2242	-	-
116_ALA	SER	8.3kJPN chr1:148202116 rs782052230	-	-	-	-
116_ALA	THR	8.3kJPN chr1:149553423 rs2451640	-	0.0107	-	-
117_ALA	VAL	gnomAD chr1:147954995 rs782288175	-	0.00126786	0.2013	-
124_GLY	ASP	8.3kJPN chr1:143767478 rs1556171825	-	0.0002	0.5713	-
124_GLY	CYS	8.3kJPN chr1:143767479 rs1556171832	-	0.0001	0.718	-
125_LYS	ARG	8.3kJPN chr1:143767475 rs1556171815	-	0.0004	0.127	-
128_ALA	VAL	gnomAD chr1:143767466 rs61824237	-	0.0277818	-	-
128_ALA	VAL	8.3kJPN chr1:143767466 rs1553321459	-	0.306	-	-
132_VAL	LEU	8.3kJPN chr1:143767455 -	-	0.0001	0.8896	-
138_ILE	THR	8.3kJPN chr1:143767436 -	-	0.0001	0.1414	-
142_MET	THR	gnomAD chr1:143767424 rs782770669	-	0.00306928	0.8612	-
142_THR	MET	gnomAD chr1:148202037 rs61809243	-	0.47619	-	-
142_THR	MET	8.3kJPN chr1:148202037 rs61809243	-	0.0071	-	-
148_ARG	GLY	8.3kJPN chr1:143767407 rs781956310	-	0.0013	0.3881	-
150_SER	ASN	gnomAD chr1:147954896 -	-	0.000102249	-	-
152_THR	SER	gnomAD chr1:147954891 -	-	0.00010353	0.5951	-
153_SER	ARG	8.3kJPN chr1:143767390 rs782408303	-	0.0001	0.676	-
153_SER	ASN	8.3kJPN chr1:143767391 -	-	0.0001	0.2227	-
158_ILE	VAL	gnomAD chr1:147954873 -	-	0.00032345	0.1022	-
161_CYS	TYR	8.3kJPN chr1:143767367 -	-	0.0001	0.9844	-
162_GLY	VAL	8.3kJPN chr1:143767364 -	-	0.0001	0.9645	-
162_GLY	ARG	8.3kJPN chr1:147954861 rs1553321430	-	0.0006	0.9117	-
164_PHE	LEU	gnomAD chr1:143767357 rs201648411	-	0.0136867	-	-
164_PHE	LEU	8.3kJPN chr1:143767357 rs201648411	-	0.1163	-	-
164_PHE	LEU	8.3kJPN chr1:144363680 -	-	0.0047	-	-
164_PHE	LEU	8.3kJPN chr1:147954853 rs1192310738	-	0.0014	-	-

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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

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Sequence information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Binding partner information

Variants

Reference

	P63098	CALCINEURIN B SUBUNIT ISOFORM 1
	Q08209	CALMODULIN-DEPENDENT CALCINEURIN A SUBUNIT, ALPHA ISOFORM

	P62937	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
	P62937	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A

	P62937	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
	P62937	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
	P62937	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
	P62937	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE