PDB ID 1AK4     CHAIN A
Protein name CYCLOPHILIN A
Uniprot Accession P62937
The number of similar proteins 196
The number of binding states 9
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state		 Binding partners
1AK4 (CHAIN: A)
1 Q72497  
2 Monomeric state
3 P01116  
4 2XGY  
5 P05092  
6 P63098   Q08209  
7 P62937   P62937  
8 P63098   P63098   Q08209   Q08209  
9 P62937   P62937   P62937   P62937  

Downdload

Format:

Molecule viewer


Only interaction residues
#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   MVNPTVFFDI   AVDGEPLGRV   SFELFADKVP   KTAENFRALS   TGEKGFGYKG   50
51   SCFHRIIPGF   MCQGGDFTRH   NGTGGKSIYG   EKFEDENFIL   KHTGPGILSM   100
101   ANAGPNTNGS   QFFICTAKTE   WLDGKHVVFG   KVKEGMNIVE   AMERFGSRNG   150
151   KTSKKITIAD   CGQLE         200

Variants

Residue AA Source dbSNP Clinical
Significance
 Allele
Frequency
(> 0.0001)		 Disease name
1_MET THR 8.3kJPN
chr1:143767847 		-
- 0.0001 -
1_MET VAL 8.3kJPN
chr1:143767848 		-
- 0.0001 -
5_VAL ALA 8.3kJPN
chr1:147955331 		rs1553321610
- 0.0001 -
6_ILE VAL gnomAD
chr1:143767833 		rs7521153
- 0.107911 -
6_ILE VAL 8.3kJPN
chr1:143767833 		rs1553321608
- 0.5 -
9_GLU ASP gnomAD
chr1:148202435 		rs782276145
- 0.00490196 -
12_VAL ILE gnomAD
chr1:147955311 		rs587649576
- 0.000381001 -
12_VAL ILE 8.3kJPN
chr1:143767815 		rs587775476
- 0.0004 -
15_LYS THR gnomAD
chr1:148202418 		-
- 0.0174419 -
17_LEU SER 8.3kJPN
chr1:143767799 		-
- 0.0001 -
20_ILE SER 8.3kJPN
chr1:148202403 		-
- 0.0001 -
20_ILE VAL 8.3kJPN
chr1:148202404 		-
- 0.0001 -
22_ILE THR gnomAD
chr1:143767784 		rs199726441
- 0.000367662 -
23_LYS GLU 8.3kJPN
chr1:143767782 		rs782571429
- 0.0001 -
24_GLN LEU gnomAD
chr1:143767778 		rs6604516
- 0.110676 -
24_GLN LEU 8.3kJPN
chr1:143767778 		rs1553321587
- 0.5 -
24_LEU GLN 8.3kJPN
chr1:148202391 		rs1310895899
- 0.0001 -
26_ALA SER 8.3kJPN
chr1:143767773 		rs1556172662
- 0.0009 -
30_LEU PRO gnomAD
chr1:144364083 		-
- 0.5 -
30_LEU PRO gnomAD
chr1:147955256 		rs199950315
- 0.00167239 -
30_PRO LEU gnomAD
chr1:148202373 		-
- 0.00281215 -
30_LEU PRO gnomAD
chr1:149553166 		-
- 0.435897 -
30_LEU PRO 8.3kJPN
chr1:144364083 		rs1553277153
- 0.26 -
30_LEU PRO 8.3kJPN
chr1:147955256 		rs199950315
- 0.1558 -
31_LYS ASN gnomAD
chr1:143767756 		rs201142708
- 0.000956015 -
31_LYS ASN 8.3kJPN
chr1:143767756 		-
- 0.0001 -
33_ALA GLU 8.3kJPN
chr1:147955247 		-
- 0.0001 -
37_ARG HIS 8.3kJPN
chr1:143767739 		rs587696524
- 0.0001 -
37_ARG HIS 8.3kJPN
chr1:148202352 		rs1179581919
- 0.0004 -
40_SER ASN gnomAD
chr1:148202343 		-
- 0.00275229 -
40_SER ARG 8.3kJPN
chr1:143767729 		-
- 0.0001 -
47_ARG CYS 8.3kJPN
chr1:143767710 		rs267597992
- 0.0002 -
47_ARG HIS 8.3kJPN
chr1:148202322 		rs1450763932
- 0.0001 -
47_ARG HIS 8.3kJPN
chr1:149553217 		rs1385929705
- 0.0011 -
50_GLY ALA 8.3kJPN
chr7:44839039 		-
- 0.0001 -
64_GLY VAL 8.3kJPN
chr1:147955154 		-
- 0.0005 -
65_GLY CYS gnomAD
chr1:147955152 		rs782191172
- 0.000107365 -
65_GLY ASP gnomAD
chr1:148202268 		-
- 0.00288684 -
65_GLY SER 8.3kJPN
chr1:143767656 		rs1556172429
- 0.0002 -
68_THR ILE gnomAD
chr1:143767646 		rs148974023
- 0.0181706 -
68_THR ILE gnomAD
chr1:148202259 		-
- 0.000674764 -
68_THR LYS 8.3kJPN
chr1:147955142 		-
- 0.0003 -
69_HIS TYR gnomAD
chr1:143767644 		rs370416528
- 0.000142119 -
69_ARG CYS gnomAD
chr1:147955140 		rs587632258
- 0.000623025 -
69_ARG HIS gnomAD
chr1:148202256 		-
- 0.101163 -
69_HIS ARG 8.3kJPN
chr1:143767643 		rs1553321535
- 0.4917 -
69_HIS TYR 8.3kJPN
chr1:143767644 		rs370416528
- 0.1097 -
69_ARG CYS 8.3kJPN
chr1:144363967 		-
- 0.0019 -
69_ARG CYS 8.3kJPN
chr1:147955140 		rs587632258
- 0.0003 -
69_ARG CYS 8.3kJPN
chr7:44839316 		rs759569570
- 0.0001 -
70_HIS PRO gnomAD
chr1:144363963 		-
- 0.5 -
70_HIS PRO gnomAD
chr1:147955136 		rs372484895
- 0.00156328 -
70_PRO HIS gnomAD
chr1:148202253 		-
- 0.0427019 -
70_HIS PRO gnomAD
chr1:149553286 		-
- 0.5 -
70_HIS PRO 8.3kJPN
chr1:144363963 		rs1556598650
- 0.0092 -
70_PRO HIS 8.3kJPN
chr1:148202253 		rs1300338652
- 0.0002 -
72_GLY ASP gnomAD
chr1:147955130 		rs587684299
- 0.00142734 -
72_GLY CYS 8.3kJPN
chr1:148202248 		-
- 0.0001 -
73_THR ALA 8.3kJPN
chr1:148202245 		rs1275248152
- 0.0001 -
74_GLY SER gnomAD
chr1:143767629 		rs12407726
- 0.00901967 -
74_GLY ASP gnomAD
chr1:147955124 		rs782544194
- 0.000115048 -
74_GLY ASP gnomAD
chr1:148202241 		rs201764814
- 0.00340716 -
74_GLY ASP 8.3kJPN
chr1:143767628 		rs1553321523
- 0.4434 -
74_GLY SER 8.3kJPN
chr1:143767629 		rs1553321527
- 0.0002 -
74_GLY ASP 8.3kJPN
chr1:148202241 		rs201764814
- 0.0081 -
75_ASP GLU gnomAD
chr1:143767624 		rs587732257
- 0.000160999 -
75_ASP GLU 8.3kJPN
chr1:143767624 		rs587732257
- 0.0004 -
76_LYS GLU 8.3kJPN
chr1:143767623 		rs782483473
- 0.0001 -
80_GLY TRP 8.3kJPN
chr1:148202224 		rs1283212414
- 0.0011 -
85_ASP ASN gnomAD
chr1:147955092 		-
- 0.000119457 -
85_ASP ASN 8.3kJPN
chr1:147955092 		rs1553321503
- 0.0001 -
88_LEU ILE 8.3kJPN
chr1:143767587 		rs1556172248
- 0.0001 -
90_ARG TER 8.3kJPN
chr1:143767581 		rs782007857
- 0.0001 -
90_ARG TER 8.3kJPN
chr1:147955077 		rs1346295031
- 0.0001 -
94_GLY ALA gnomAD
chr1:143767568 		rs377521864
- 0.00100786 -
94_GLY SER gnomAD
chr1:143767569 		rs587598335
- 0.00110918 -
94_GLY VAL 8.3kJPN
chr1:143767568 		rs377521864
- - -
94_GLY SER 8.3kJPN
chr1:143767569 		rs587598335
- 0.0001 -
97_ILE PHE 8.3kJPN
chr1:143767560 		rs781805323
- 0.0001 -
98_LEU PHE gnomAD
chr1:147955051 		-
- 0.000121489 -
98_LEU TER 8.3kJPN
chr1:147955052 		-
- 0.0001 -
101_ALA VAL 8.3kJPN
chr1:143767547 		rs1553321483
- 0.4823 -
101_ALA VAL 8.3kJPN
chr1:144363870 		-
- 0.0238 -
101_ALA VAL 8.3kJPN
chr1:148202160 		rs781828336
- 0.0021 -
102_ASN ILE gnomAD
chr1:143767544 		rs781911564
- 0.0016785 -
106_ASN SER 8.3kJPN
chr1:147955028 		-
- 0.0001 -
108_ASN SER gnomAD
chr1:148202139 		-
- 0.0842391 -
108_ASN SER 8.3kJPN
chr1:148202139 		rs1469676804
- 0.0004 -
112_PHE LEU 8.3kJPN
chr1:143767513 		rs1553321469
- 0.4885 -
112_PHE LEU 8.3kJPN
chr1:144363836 		-
- 0.0427 -
112_PHE LEU 8.3kJPN
chr1:148202126 		rs1553648642
- 0.0009 -
115_CYS PHE 8.3kJPN
chr1:143767505 		rs1556171913
- 0.0002 -
116_THR ASN 8.3kJPN
chr1:143767502 		-
- 0.0001 -
116_ALA THR 8.3kJPN
chr1:144363826 		-
- 0.2242 -
116_ALA SER 8.3kJPN
chr1:148202116 		rs782052230
- - -
116_ALA THR 8.3kJPN
chr1:149553423 		rs2451640
- 0.0107 -
117_ALA VAL gnomAD
chr1:147954995 		rs782288175
- 0.00126786 -
124_GLY ASP 8.3kJPN
chr1:143767478 		rs1556171825
- 0.0002 -
124_GLY CYS 8.3kJPN
chr1:143767479 		rs1556171832
- 0.0001 -
125_LYS ARG 8.3kJPN
chr1:143767475 		rs1556171815
- 0.0004 -
128_ALA VAL gnomAD
chr1:143767466 		rs61824237
- 0.0277818 -
128_ALA VAL 8.3kJPN
chr1:143767466 		rs1553321459
- 0.306 -
132_VAL LEU 8.3kJPN
chr1:143767455 		-
- 0.0001 -
138_ILE THR 8.3kJPN
chr1:143767436 		-
- 0.0001 -
142_MET THR gnomAD
chr1:143767424 		rs782770669
- 0.00306928 -
142_THR MET gnomAD
chr1:148202037 		rs61809243
- 0.47619 -
142_THR MET 8.3kJPN
chr1:148202037 		rs61809243
- 0.0071 -
148_ARG GLY 8.3kJPN
chr1:143767407 		rs781956310
- 0.0013 -
150_SER ASN gnomAD
chr1:147954896 		-
- 0.000102249 -
152_THR SER gnomAD
chr1:147954891 		-
- 0.00010353 -
153_SER ARG 8.3kJPN
chr1:143767390 		rs782408303
- 0.0001 -
153_SER ASN 8.3kJPN
chr1:143767391 		-
- 0.0001 -
158_ILE VAL gnomAD
chr1:147954873 		-
- 0.00032345 -
161_CYS TYR 8.3kJPN
chr1:143767367 		-
- 0.0001 -
162_GLY VAL 8.3kJPN
chr1:143767364 		-
- 0.0001 -
162_GLY ARG 8.3kJPN
chr1:147954861 		rs1553321430
- 0.0006 -
164_PHE LEU gnomAD
chr1:143767357 		rs201648411
- 0.0136867 -
164_PHE LEU 8.3kJPN
chr1:143767357 		rs201648411
- 0.1163 -
164_PHE LEU 8.3kJPN
chr1:144363680 		-
- 0.0047 -
164_PHE LEU 8.3kJPN
chr1:147954853 		rs1192310738
- 0.0014 -
(Powered by wupsivus)

Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.