| PDB ID | 1A8M
|
CHAIN | A |
|---|---|---|---|
| Protein name | TUMOR NECROSIS FACTOR ALPHA | ||
| Uniprot Accession | P01375 | ||
| The number of similar proteins | 95 | ||
| The number of binding states | 13 | ||
| The number of binding partners | 7 | ||
Coloring
Unicolor (beige)
The number of binding partners
Group
| Binding state |
Binding partners |
|---|---|
| 1A8M (CHAIN: A) | |
| 1 |
P01375
P01375
|
| 2 | Monomeric state |
| 3 |
P01375
|
| 4 |
7TA3
|
| 5 |
3L9J
|
| 6 |
3WD5
3WD5
|
| 7 |
P01375
P01375
5M2M
|
| 8 |
P01375
P01375
P01375
|
| 9 |
P01375
P01375
P19438
P19438
|
| 10 |
P01375
P01375
5M2I
5M2I
|
| 11 |
P01375
P01375
5YOY
5YOY
|
| 12 |
P01375
P01375
Q9DHW0
Q9DHW0
|
| 13 |
P01375
P01375
7KPB
7KPB
P19438
|
Downdload
Molecule viewer
|
Only interaction residues |
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Sequence information
|
Variants
| Residue | AA | Source / dbSNP |
Clinical Significance |
Allele Frequency (> 0.0001) |
AlphaMissense pathogenicity |
Disease name | |
|---|---|---|---|---|---|---|---|
| 8_PRO | LEU |
VAR_019378
rs4645843 |
LB/B | - | 0.082 | - | |
| 8_PRO | LEU |
gnomAD chr6:31544562 rs4645843 |
- | 0.002562 | 0.082 | - | |
| 18_ALA | THR |
VAR_011927
rs1800620 |
LB/B | - | 0.6562 | - | |
| 32_ARG | TRP |
ClinVar chr6:31544934 rs281865419 |
Pathogenic | - | 0.1812 | TNF receptor binding, altered [MedGen:C4016415] | |
| 41_VAL | MET |
8.3kJPN chr6:31544961 rs548532642 |
- | 0.0001 | 0.1252 | - | |
| 72_THR | SER |
8.3kJPN chr6:31545055 - |
- | 0.0001 | 0.0587 | - | |
| 85_VAL | ILE |
gnomAD chr6:31545093 rs373646181 |
- | 0.000101197 | 0.088 | - | |
| 85_VAL | ILE |
8.3kJPN chr6:31545093 rs373646181 |
- | 0.0002 | 0.088 | - | |
| 103_ARG | LYS |
8.3kJPN chr6:31545148 - |
- | 0.0001 | 0.0727 | - | |
| 118_ILE | ASN |
gnomAD chr6:31545193 rs11574936 |
- | 0.000352864 | 0.8326 | - | |
| 118_ILE | ASN |
8.3kJPN chr6:31545193 rs11574936 |
- | 0.0004 | 0.8326 | - | |
| 138_ARG | GLN |
8.3kJPN chr6:31545253 rs770509340 |
- | 0.0001 | 0.071 | - | |
| 140_ASP | ASN |
8.3kJPN chr6:31545258 rs370893734 |
- | 0.0001 | 0.0729 | - | |
| 146_GLU | ASP |
8.3kJPN chr6:31545278 - |
- | 0.0001 | 0.1529 | - |