PDB ID 3PRX     CHAIN A
Protein name Complement C5
Uniprot Accession P01031
The number of similar proteins 7
The number of binding states 7
The number of binding partners 6

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
3PRX (CHAIN: A)
1 Q91132   D3JIB2  
2 Monomeric state
3 Q91132  
4 Q6GJP2  
5 A6QE84  
6 P13671  
7 5I5K   5I5K  

Downdload

Format:

Molecule viewer

#binding
partners
  3
  2
  1
  0

Sequence information

1   MGLLGILCFL   IFLGKTWGQE   QTYVISAPKI   FRVGASENIV   IQVYGYTEAF   50
51   DATISIKSYP   DKKFSYSSGH   VHLSSENKFQ   NSAILTIQPK   QLPGGQNPVS   100
101   YVYLEVVSKH   FSKSKRMPIT   YDNGFLFIHT   DKPVYTPDQS   VKVRVYSLND   150
151   DLKPAKRETV   LTFIDPEGSE   VDMVEEIDHI   GIISFPDFKI   PSNPRYGMWT   200
201   IKAKYKEDFS   TTGTAYFEVK   EYVLPHFSVS   IEPEYNFIGY   KNFKNFEITI   250
251   KARYFYNKVV   TEADVYITFG   IREDLKDDQK   EMMQTAMQNT   MLINGIAQVT   300
301   FDSETAVKEL   SYYSLEDLNN   KYLYIAVTVI   ESTGGFSEEA   EIPGIKYVLS   350
351   PYKLNLVATP   LFLKPGIPYP   IKVQVKDSLD   QLVGGVPVTL   NAQTIDVNQE   400
401   TSDLDPSKSV   TRVDDGVASF   VLNLPSGVTV   LEFNVKTDAP   DLPEENQARE   450
451   GYRAIAYSSL   SQSYLYIDWT   DNHKALLVGE   HLNIIVTPKS   PYIDKITHYN   500
501   YLILSKGKII   HFGTREKFSD   ASYQSINIPV   TQNMVPSSRL   LVYYIVTGEQ   550
551   TAELVSDSVW   LNIEEKCGNQ   LQVHLSPDAD   AYSPGQTVSL   NMATGMDSWV   600
601   ALAAVDSAVY   GVQRGAKKPL   ERVFQFLEKS   DLGCGAGGGL   NNANVFHLAG   650
651   LTFLTNANAD   DSQENDEPCK   EILRPRRTLQ   KKIEEIAAKY   KHSVVKKCCY   700
701   DGACVNNDET   CEQRAARISL   GPRCIKAFTE   CCVVASQLRA   NISHKDMQLG   750
751   RLHMKTLLPV   SKPEIRSYFP   ESWLWEVHLV   PRRKQLQFAL   PDSLTTWEIQ   800
801   GVGISNTGIC   VADTVKAKVF   KDVFLEMNIP   YSVVRGEQIQ   LKGTVYNYRT   850
851   SGMQFCVKMS   AVEGICTSES   PVIDHQGTKS   SKCVRQKVEG   SSSHLVTFTV   900
901   LPLEIGLHNI   NFSLETWFGK   EILVKTLRVV   PEGVKRESYS   GVTLDPRGIY   950
951   GTISRRKEFP   YRIPLDLVPK   TEIKRILSVK   GLLVGEILSA   VLSQEGINIL   1000
1001   THLPKGSAEA   ELMSVVPVFY   VFHYLETGNH   WNIFHSDPLI   EKQKLKKKLK   1050
1051   EGMLSIMSYR   NADYSYSVWK   GGSASTWLTA   FALRVLGQVN   KYVEQNQNSI   1100
1101   CNSLLWLVEN   YQLDNGSFKE   NSQYQPIKLQ   GTLPVEAREN   SLYLTAFTVI   1150
1151   GIRKAFDICP   LVKIDTALIK   ADNFLLENTL   PAQSTFTLAI   SAYALSLGDK   1200
1201   THPQFRSIVS   ALKREALVKG   NPPIYRFWKD   NLQHKDSSVP   NTGTARMVET   1250
1251   TAYALLTSLN   LKDINYVNPV   IKWLSEEQRY   GGGFYSTQDT   INAIEGLTEY   1300
1301   SLLVKQLRLS   MDIDVSYKHK   GALHNYKMTD   KNFLGRPVEV   LLNDDLIVST   1350
1351   GFGSGLATVH   VTTVVHKTST   SEEVCSFYLK   IDTQDIEASH   YRGYGNSDYK   1400
1401   RIVACASYKP   SREESSSGSS   HAVMDISLPT   GISANEEDLK   ALVEGVDQLF   1450
1451   TDYQIKDGHV   ILQLNSIPSS   DFLCVRFRIF   ELFEVGFLSP   ATFTVYEYHR   1500
1501   PDKQCTMFYS   TSNIKIQKVC   EGAACKCVEA   DCGQMQEELD   LTISAETRKQ   1550
1551   TACKPEIAYA   YKVSITSITV   ENVFVKYKAT   LLDIYKTGEA   VAEKDSEITF   1600
1601   IKKVTCTNAE   LVKGRQYLIM   GKEALQIKYN   FSFRYIYPLD   SLTWIEYWPR   1650
1651   DTTCSSCQAF   LANLDEFAED   IFLNGC       1700

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
49_ALA VAL 4.7kJPN
chr9:123808581
-
- 0.0001 -
72_HIS ASN 4.7kJPN
chr9:123808513
rs1239344218
- 0.0006 -
108_SER TER 4.7kJPN
chr9:123805380
-
- 0.0001 -
145_VAL ILE VAR_038735 rs17216529
Polymorphism - -
145_VAL ILE 4.7kJPN
chr9:123800218
rs17216529
- 0.1991 -
164_ILE LYS 4.7kJPN
chr9:123800160
-
- 0.0001 -
171_VAL ALA 4.7kJPN
chr9:123797153
rs185695138
- 0.0016 -
238_ILE THR 4.7kJPN
chr9:123792720
rs567288479
- 0.0001 -
238_ILE VAL 4.7kJPN
chr9:123792721
-
- 0.0001 -
265_VAL ILE 4.7kJPN
chr9:123789518
rs148539497
- 0.0002 -
274_ASP GLY 4.7kJPN
chr9:123789490
-
- 0.0001 -
280_LYS ASN 4.7kJPN
chr9:123789471
-
- 0.0014 -
281_GLU ASP 4.7kJPN
chr9:123789468
rs201821112
- 0.0001 -
297_ALA VAL 4.7kJPN
chr9:123787842
rs1269751460
- 0.0001 -
339_GLU GLY 4.7kJPN
chr9:123785782
-
- 0.0004 -
354_LEU MET VAR_048822 rs34552775
Polymorphism - -
372_LYS ARG ClinVar
chr9:123785683
rs587776846
Pathogenic - Leiner disease [MedGen:C0343047,OMIM:609536]
389_THR ILE VAR_023946 -
Polymorphism - -
405_ASP HIS 4.7kJPN
chr9:123783876
-
- 0.0002 -
417_VAL ALA 4.7kJPN
chr9:123783839
-
- 0.0002 -
449_ARG GLY VAR_038736 rs2230213
Polymorphism - -
451_GLY VAL 4.7kJPN
chr9:123782408
rs56188613
- 0.0104 -
493_ILE MET 4.7kJPN
chr9:123782281
-
- 0.0001 -
514_THR MET 4.7kJPN
chr9:123780096
rs199664327
- 0.0031 -
515_ARG LYS 4.7kJPN
chr9:123780093
rs1423414968
- 0.0001 -
518_PHE SER VAR_001996 -
Polymorphism - -
572_GLN ARG 4.7kJPN
chr9:123779922
-
- 0.0001 -
600_VAL GLU 4.7kJPN
chr9:123779707
-
- 0.0001 -
605_VAL LEU 4.7kJPN
chr9:123779693
-
- 0.0002 -
647_HIS GLN 4.7kJPN
chr9:123778587
rs202080772
- 0.0002 -
714_ARG TER 4.7kJPN
chr9:123776268
-
- 0.0001 -
734_VAL ILE 4.7kJPN
chr9:123776208
rs771791383
- 0.0004 -
756_THR ILE 4.7kJPN
chr9:123770767
rs1456300999
- 0.0002 -
802_VAL ILE VAR_014574 rs17611
Polymorphism - -
802_VAL ILE 4.7kJPN
chr9:123769200
rs17611
- 0.5217 -
885_ARG CYS VAR_071067 rs373359894
Polymorphism - -
885_ARG HIS VAR_071068 rs56040400
Polymorphism - -
885_ARG HIS 4.7kJPN
chr9:123759961
rs56040400
- 0.019 -
907_LEU PHE 4.7kJPN
chr9:123759896
rs772788429
- 0.001 -
928_ARG GLN VAR_038737 rs41309892
Polymorphism - -
933_GLY VAL VAR_038738 rs41309902
Polymorphism - -
966_ASP TYR VAR_048823 rs2230212
Polymorphism - -
966_ASP TYR 4.7kJPN
chr9:123753514
rs2230212
- 0.0314 -
1006_GLY ALA 4.7kJPN
chr9:123751983
rs754352144
- 0.0006 -
1015_VAL ILE 4.7kJPN
chr9:123751957
rs765069093
- 0.0001 -
1033_ILE THR VAR_038739 rs41311881
Polymorphism - -
1037_ASP ASN VAR_038740 rs41311883
Polymorphism - -
1043_GLN LYS VAR_038741 rs41311887
Polymorphism - -
1053_MET LEU VAR_014575 rs17609
Polymorphism - -
1310_SER ASN VAR_014576 rs17610
Polymorphism - -
1325_ASN SER 4.7kJPN
chr9:123737100
-
- 0.0001 -
1336_ARG LYS 4.7kJPN
chr9:123737067
-
- 0.0002 -
1365_VAL ALA VAR_048824 rs16910245
Polymorphism - -
1405_CYS ARG 4.7kJPN
chr9:123731346
rs753067140
- 0.0001 -
1437_GLU ASP VAR_014577 rs17612
Polymorphism - -
1437_GLU ASP 4.7kJPN
chr9:123725926
rs17612
- 0.0002 -
1454_GLN ARG 4.7kJPN
chr9:123725208
-
- 0.0001 -
1476_ARG TER ClinVar
chr9:123725027
rs121909588
Pathogenic - Leiner disease [MedGen:C0343047,OMIM:609536]
1478_ARG TRP 4.7kJPN
chr9:123725021
rs138933092
- 0.0003 -
1499_HIS GLN 4.7kJPN
chr9:123724956
-
- 0.0001 -
1538_GLU TER 4.7kJPN
chr9:123722592
-
- 0.0002 -
1540_ASP ASN 4.7kJPN
chr9:123722586
rs755260495
- 0.0005 -
1654_CYS ARG 4.7kJPN
chr9:123715088
rs748755309
- 0.0001 -
1662_ALA VAL 4.7kJPN
chr9:123715063
-
- 0.0001 -
1670_ASP HIS 4.7kJPN
chr9:123715040
rs761048515
- 0.0005 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.