PDB ID 2PMW     CHAIN B
Protein name Proprotein convertase subtilisin/kexin type 9
Uniprot Accession Q5SZQ2
The number of similar proteins 13
The number of binding states 5
The number of binding partners 5

Coloring

Unicolor (beige)

The number of binding partners

Group

Binding
state
Binding partners
2PMW (CHAIN: B)
1 Q5SZQ2  
2 Q8NBP7   Q59FQ1  
3 Q8NBP7   P01130  
4 Q8NBP7   3SQO   3SQO  
5 Q8NBP7   5VL7   5VL7  

Downdload

Format:

Molecule viewer

#binding
partners
  5
  4
  3
  2
  1
  0

Sequence information

1   SIPWNLERIT   PPRYRADEYQ   PPDGGSLVEV   YLLDTSIQSD   HREIEGRVMV   50
51   TDFENVPEED   GTRFHRQASK   CDSHGTHLAG   VVSGRDAGVA   KGASMRSLRV   100
101   LNCQGKGTVS   GTLIGLEFIR   KSQLVQPVGP   LVVLLPLAGG   YSRVLNAACQ   150
151   RLARAGVVLV   TAAGNFRDDA   CLYSPASAPE   VITVGATNAQ   DQPVTLGTLG   200
201   TNFGRCVDLF   APGEDIIGAS   SDCSTCFVSQ   SGTSQAAAHV   AGIAAMMLSA   250
251   EPELTLAELR   QRLIHFSAKD   VINEAWFPED   QRVLTPNLVA   ALPPSTHGAG   300
301   WQLFCRTVWS   AHSGPTRMAT   AVARCAPDEE   LLSCSSFSRS   GKRRGERMEA   350
351   QGGKLVCRAH   NAFGGEGVYA   IARCCLLPQA   NCSVHTAPPA   EASMGTRVHC   400
401   HQQGHVLTGC   SSHWEVEDLG   THKPPVLRPR   GQPNQCVGHR   EASIHASCCH   450
451   APGLECKVKE   HGIPAPQEQV   TVACEEGWTL   TGCSALPGTS   HVLGAYAVDN   500
501   TCVVRSRDVS   TTGSTSEGAV   TAVAICCRSR   HLAQASQELQ     550

Variants

Residue AA Source dbSNP Clinical
Significance
Allele
Frequency
(4.7kJPN)
Disease name
153_SER ASN 4.7kJPN
chr1:55512254
-
- 0.0001 -
204_ASP ASN ClinVar
chr1:55518037
rs793888521
Likely pathogenic - Familial hypercholesterolemia [MedGen:C0745103,OMIM:143890,SNOMED CT:397915002,SNOMED CT:398036000]
209_PRO LEU 4.7kJPN
chr1:55518053
-
- 0.0001 -
219_GLN GLU 4.7kJPN
chr1:55518082
rs778617372
- 0.0001 -
220_ALA THR ClinVar
chr1:55518323
rs768795323
Pathogenic - Familial hypercholesterolemia [MedGen:C0745103,OMIM:143890,SNOMED CT:397915002,SNOMED CT:398036000]
233_VAL ALA 4.7kJPN
chr1:55518363
-
- 0.0001 -
236_GLY SER 4.7kJPN
chr1:55518371
rs149489325
- 0.0001 -
237_ARG TRP 4.7kJPN
chr1:55518374
rs148195424
- 0.0001 -
246_SER ASN 4.7kJPN
chr1:55518402
-
- 0.0001 -
248_ARG CYS 4.7kJPN
chr1:55518407
rs779824389
- 0.0002 -
263_GLY SER 4.7kJPN
chr1:55518452
rs200146448
- 0.0071 -
264_THR ILE 4.7kJPN
chr1:55518456
rs201789841
- 0.0053 -
310_VAL MET 4.7kJPN
chr1:55521794
rs1200999906
- 0.0001 -
323_CYS SER 4.7kJPN
chr1:55521834
rs1307302473
- 0.0001 -
354_ASN ILE ClinVar
chr1:55523068
rs1553137543
Likely pathogenic - Familial hypercholesterolemia [MedGen:C0745103,OMIM:143890,SNOMED CT:397915002,SNOMED CT:398036000]
374_ASP TYR ClinVar
chr1:55523127
rs137852912
Pathogenic/Likely pathogenic - Familial hypercholesterolemia [MedGen:C0745103,OMIM:143890,SNOMED CT:397915002,SNOMED CT:398036000]; Hypercholesterolemia, autosomal dominant, 3 [MedGen:C1863551,OMIM:603776]
374_ASP HIS ClinVar
chr1:55523127
rs137852912
Pathogenic - Familial hypercholesterolemia [MedGen:C0745103,OMIM:143890,SNOMED CT:397915002,SNOMED CT:398036000]
378_CYS TRP 4.7kJPN
chr1:55523141
rs776752113
- 0.0001 -
392_VAL MET ClinVar
chr1:55523181
rs1254346075
Pathogenic - Familial hypercholesterolemia [MedGen:C0745103,OMIM:143890,SNOMED CT:397915002,SNOMED CT:398036000]
412_ARG LYS 4.7kJPN
chr1:55523763
rs775522541
- 0.0001 -
424_ILE VAL 4.7kJPN
chr1:55523798
rs759250273
- 0.008 -
428_TRP TER 4.7kJPN
chr1:55523812
-
- 0.0007 -
467_PRO ALA ClinVar
chr1:55524216
rs772677312
Likely pathogenic - Familial hypercholesterolemia [MedGen:C0745103,OMIM:143890,SNOMED CT:397915002,SNOMED CT:398036000]
467_PRO LEU 4.7kJPN
chr1:55524217
-
- 0.0001 -
468_THR ALA ClinVar
chr1:55524219
rs1553137693
Pathogenic - Familial hypercholesterolemia [MedGen:C0745103,OMIM:143890,SNOMED CT:397915002,SNOMED CT:398036000]
471_ALA SER ClinVar
chr1:55524228
rs1553137699
Pathogenic - Familial hypercholesterolemia [MedGen:C0745103,OMIM:143890,SNOMED CT:397915002,SNOMED CT:398036000]
474_VAL ILE 4.7kJPN
chr1:55524237
rs562556
- 0.9711 -
476_ARG CYS ClinVar
chr1:55524243
rs761767572
Pathogenic - Familial hypercholesterolemia [MedGen:C0745103,OMIM:143890,SNOMED CT:397915002,SNOMED CT:398036000]
495_ARG TRP 4.7kJPN
chr1:55524300
rs758999339
- 0.0001 -
499_ARG CYS 4.7kJPN
chr1:55524312
rs201395805
- 0.0002 -
504_GLY TRP 4.7kJPN
chr1:55525165
rs374455190
- 0.0001 -
513_ASN ASP ClinVar
chr1:55525192
rs1057516136
Likely pathogenic - Familial hypercholesterolemia [MedGen:C0745103,OMIM:143890,SNOMED CT:397915002,SNOMED CT:398036000]
514_ALA THR 4.7kJPN
chr1:55525195
rs1447116791
- 0.0002 -
522_ALA THR 4.7kJPN
chr1:55525219
rs777300852
- 0.0002 -
549_ARG PRO 4.7kJPN
chr1:55525301
-
- 0.0001 -
589_VAL MET 4.7kJPN
chr1:55527131
rs372586224
- 0.0001 -
592_ARG THR 4.7kJPN
chr1:55527141
-
- 0.0002 -
598_ALA THR 4.7kJPN
chr1:55527158
rs367606156
- 0.0002 -
629_GLY ASP 4.7kJPN
chr1:55529064
rs1261496250
- 0.0006 -
644_VAL ILE 4.7kJPN
chr1:55529108
rs143291739
- 0.0041 -
659_ARG GLY 4.7kJPN
chr1:55529153
rs147182054
- 0.0002 -
670_GLY GLU 4.7kJPN
chr1:55529187
rs505151
- 0.952 -
675_VAL ILE 4.7kJPN
chr1:55529201
rs760981278
- 0.0001 -
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Reference

PiSite: a database of protein interaction sites using multiple binding states in the PDB, Miho Higurashi, Takashi Ishida and Kengo Kinoshita, Nucleic Acids Research 2009 37(Database issue):D360-D364

COPYRIGHTc2008-2019 Miho Higurashi, Takashi Ishida and Kengo Kinoshita. All rights reserved.